H 151 NEW
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
CAS: 941987-60-6
Molecular Formula: C17H17N3O
H 151 NEW - Names and Identifiers
| Name | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea |
| Synonyms | H151 H-151 H 151 NEW STING inhibitor STING ANTAGONIST STING antagonist N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl- |
| CAS | 941987-60-6 |
H 151 NEW - Physico-chemical Properties
| Molecular Formula | C17H17N3O |
| Molar Mass | 279.34 |
| Density | 1.298±0.06 g/cm3(Predicted) |
| Boling Point | 399.9±25.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | solid |
| Color | Off-white |
| pKa | 14.96±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Use | H-151 is an efficient, selective and covalent STING antagonist, which can reduce phosphorylation of TBK1 and inhibit palmitoylation of human STING. |
| In vitro study | H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells. H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells. H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation. |
| In vivo study | H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice. H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1 −/− mice that expressed a bioluminescent IFNβ reporter. H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice. |
H 151 NEW - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.58 ml | 17.9 ml | 35.799 ml |
| 5 mM | 0.716 ml | 3.58 ml | 7.16 ml |
| 10 mM | 0.358 ml | 1.79 ml | 3.58 ml |
| 5 mM | 0.072 ml | 0.358 ml | 0.716 ml |
Last Update：2024-01-02 23:10:35
H 151 NEW - Introduction
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea is the name of a chemical substance that has no specific chemical formula or structure. Therefore, I am unable to provide information on the specific nature, use, formulation and safety of 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea. If you can provide more background information about 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea, such as chemical formula or structure, I will be able to give you a more detailed answer.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Visit Supplier Webpage Request for quotationCAS: 941987-60-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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